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Task demand modulation of steady-state functional connectivity to primary motor cortex.

Allen T Newton1, Victoria L Morgan, John C Gore

  • 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37232-2310, USA. allen.t.newton@vanderbilt.edu

Human Brain Mapping
|November 3, 2006
PubMed
Summary

Task demand significantly alters brain functional connectivity. Increased tapping rates during functional MRI scans modulated correlations between motor regions, suggesting BOLD signal fluctuations reflect task-specific neural communication.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Functional Neuroimaging

Background:

  • Blood oxygen level-dependent (BOLD) MRI signals reveal functional brain connectivity through interregional correlations.
  • Steady-state correlation measures are valuable as they are independent of task design.
  • Task conditions can influence measured functional connectivity indices.

Purpose of the Study:

  • To investigate how task demand, specifically tapping rate, affects interregional correlations within the human motor system.
  • To determine the impact of varying tapping speeds on functional connectivity to the contralateral primary motor cortex (PM).

Main Methods:

  • Utilized audibly paced finger-tapping tasks with controlled and varied tapping rates during functional MRI.
  • Analyzed steady-state BOLD signal correlations between primary motor cortex (PM) and regions of interest (supplementary motor area, cerebellum, auditory cortex).
  • Examined changes in mean correlation and the proportion of significantly correlated voxels.

Main Results:

  • Tapping rate significantly influenced the mean correlation between some motor regions and PM.
  • Interregional correlations during tapping tasks were generally higher compared to resting state.
  • Increased mean correlations were explained by a greater percentage of significantly correlated voxels within regions.

Conclusions:

  • Steady-state functional connectivity is sensitive to task demands, specifically motor task intensity.
  • Changes in functional connectivity reflect alterations in the proportion of actively communicating neural populations.
  • Low-frequency BOLD signal fluctuations reliably indicate task-dependent functional connectivity.