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Updated: May 2, 2026

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Published on: February 15, 2016
[Development of a gas chromatography-mass spectrometry method for the quantification of propofol in blood]
1The people's Procuratorate of Huzhou, Huzhou 313000, China.
Objective:
A rapid and selective method has been developed for the determination of propofol in blood by gas chromatography-mass spectrometry (GC-MS).
Methods:
The blood was extrasted with the solution of internal standard, the extracted residue was analyzed by gas chromatography-mass spectrometry using selected-ion monitoring mode.
Results:
The linear range was 0.1-10 microg/mL. The coefficient(R2) was 0.993 1. The detection limit was 0.05 microg/mL.
Conclusion:
The method is simple and rapid, offering superior sensitivity and selectivity for propofol. The method can be used successfully during clinical and forensic toxicology.
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