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Updated: Jul 19, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp
Daniela Weber1, Gilda Erosa, Olov Sterner
1Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.
Abstract:
In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 microM. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.
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