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Updated: Jul 19, 2026

Imaging and Analysis of Neurofilament Transport in Excised Mouse Tibial Nerve
Published on: August 31, 2020
Heterogeneous inclusions in neurofilament inclusion disease
Hirotake Uchikado1, Ang Li, Wen-Lang Lin
1Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA.
Abstract:
Neurofilament inclusion disease (NFID) is a rare disease, whose pathogenesis remains to be elucidated. Immunoreactivity of ubiquitin-binding protein p62 has been reported in various neurodegenerative diseases, but it has not been studied in NFID. In this report we show p62 immunoreactivity in neuronal perikaryon of three cases of NFID. We found inclusions in NFID to be heterogenous based on immunoreactivity for alpha-internexin, phosphorylated neurofilament-H, p62 and ubiquitin. Moreover, we showed both p62- and alpha-internexin-immunoreactive inclusions within the perikarya of the same neuron. Electron microscopy findings support the notion that inclusions in NFID are heterogenous. The present study extends the list of proteins that have been identified as components of neuronal inclusions in NFID, and may help account for the pathogenesis of NFID.
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