Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Operational challenges in adaptive design implementation.

Paul Gallo1

  • 1Novartis Pharmaceuticals, B&SR, One Health Plaza, East Hanover, NJ 07936, USA. paul.gallo@novartis.com

Pharmaceutical Statistics
|November 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-Center Experience with Sonic Estimation of Elasticity via Resonance (SEER)-Guided Hemostasis in Adult Cardiac Surgical Patients.

Journal of cardiothoracic and vascular anesthesia·2025
Same author

Variation in Hospitalization Costs, Charges, and Lengths of Hospital Stay for Coronavirus Disease 2019 Patients Treated With Venovenous Extracorporeal Membrane Oxygenation in the United States: A Cohort Study.

Journal of cardiothoracic and vascular anesthesia·2023
Same author

Challenges in Implementing Futility Schemes, with Reference to Aducanumab.

Therapeutic innovation & regulatory science·2023
Same author

Challenges in Assessing the Impact of the COVID-19 Pandemic on the Integrity and Interpretability of Clinical Trials.

Statistics in biopharmaceutical research·2021
Same author

Lessons Learned From Multi-regional Trials With Signals of Treatment Effect Heterogeneity.

Therapeutic innovation & regulatory science·2020
Same author

Presenting Risks and Benefits: Helping the Data Monitoring Committee Do Its Job.

Annals of internal medicine·2019
Same journal

Impact of Information Leakage in Platform Trials With Survival Endpoints on Type I Error Control.

Pharmaceutical statistics·2026
Same journal

Harmonic Fowlkes-Mallows Index for Medical Diagnostics Tests and Optimal Cut-Off Point Selection of Binary Diseases.

Pharmaceutical statistics·2026
Same journal

Early Phase Dose-Finding Designs for CAR-T Cell Therapies.

Pharmaceutical statistics·2026
Same journal

Optimizing Randomization Ratios in Clinical Trials With Survival Endpoints.

Pharmaceutical statistics·2026
Same journal

CUI-MET: A Clinical Utility Index Based Analysis and Decision Framework for Dose Optimization in Multiple-Dose, Multiple-Outcome Randomized Trials.

Pharmaceutical statistics·2026
Same journal

Will the Pharmaceutical Industry Need Statisticians in an AI World?

Pharmaceutical statistics·2026
See all related articles

Adaptive clinical trials require careful management of interim data analysis and review to maintain trial integrity. This discussion addresses operational models and potential concerns regarding sponsor involvement and information leakage during adaptive trial adaptations.

Failed At:

2026-06-19T13:35:59.130776+00:00

Related Experiment Videos