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Updated: Jul 19, 2026

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Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Percutaneous closure of ventricular septal defects
Gianfranco Butera1, Massimo Chessa, Luciane Piazza
1Istituto Policlinico San Donato, Pediatric Cardiology, Via Morandi, 30--20097 San Donato, Milanese, Italy. gianfra.but@lycos.com
Expert Review of Cardiovascular Therapy
|November 4, 2006
Summary
Surgical repair of isolated ventricular septal defects, the most common congenital heart defect, carries risks. Percutaneous closure offers a less invasive alternative for muscular and perimembranous defects.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Congenital Heart Disease
Background:
- Isolated ventricular septal defect (VSD) is the most prevalent congenital heart anomaly.
- Surgical VSD closure is the established treatment but involves significant morbidity and mortality risks.
Purpose of the Study:
- To evaluate percutaneous closure as a viable alternative to surgery for VSD treatment.
- To assess the efficacy and safety of less invasive VSD closure techniques.
Main Methods:
- Review of current literature on surgical and percutaneous VSD closure.
- Analysis of outcomes, complications, and patient selection for both approaches.
Main Results:
- Surgical VSD repair remains the gold standard but is associated with known risks.
- Percutaneous closure has emerged as a feasible alternative for specific VSD types (muscular, perimembranous).
Conclusions:
- Percutaneous closure represents a promising, less invasive option for select VSD patients.
- Further research and standardization of percutaneous techniques are warranted to optimize outcomes.

