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Substance P affects the GABAergic system in the hypothalamo-pituitary axis
S Afione1, L Debeljuk, A Seilicovich
1Centro de Investigaciones en Reproducción, Facultad de Medicina Universidad de Buenos Aires, Argentina.
Peptides
|November 1, 1990
Summary
Neutralizing substance P with anti-substance P serum (ASPS) reversed hyperprolactinemia-induced increases in anterior pituitary GABA. Substance P influences GABA release and concentration, suggesting a key interaction.
Area of Science:
- Neuroendocrinology
- Neurochemistry
Background:
- Hyperprolactinemia, often induced by 5-hydroxytryptophan or pituitary grafts, alters neurotransmitter levels.
- Substance P and GABA are key neurochemicals involved in pituitary function.
Purpose of the Study:
- To investigate the role of endogenous substance P in regulating GABA concentration in the anterior pituitary during hyperprolactinemia.
- To elucidate the interaction between substance P and GABAergic systems in the hypothalamus and anterior pituitary.
Main Methods:
- Administration of anti-substance P serum (ASPS) to neutralize endogenous substance P in hyperprolactinemic rat models.
- In vitro experiments measuring GABA efflux from hypothalamic fragments and GABA concentration in the anterior pituitary.
Main Results:
- ASPS administration significantly reduced the elevated anterior pituitary GABA levels associated with hyperprolactinemia.
- In vitro, substance P inhibited potassium-evoked GABA release from hypothalamic tissue and decreased anterior pituitary GABA.
- Conversely, ASPS treatment in vitro increased anterior pituitary GABA concentration.
Conclusions:
- Endogenous substance P plays a crucial role in modulating hypothalamic GABA release and anterior pituitary GABA concentration.
- A significant interaction between substance P and GABAergic neurotransmission exists within the neuroendocrine system.
- Targeting the substance P pathway may offer novel therapeutic strategies for conditions involving altered GABAergic signaling.