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[The autonomic pupillary dysfunction in type II diabetes mellitus]
Ya-Bo Yang1, Yi-Bo Yu, Qing Fu
1Department of Ophthalmology, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China. yabyang@hotmail.com
[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|November 4, 2006
Summary
Pupillary dysfunction is an early indicator of autonomic neuropathy in type II diabetes mellitus. Pupil diameter and response to light and dilation reliably detect this condition.
Area of Science:
- Ophthalmology
- Neurology
- Endocrinology
Context:
- Diabetic autonomic neuropathy affects various bodily systems, including the autonomic control of the pupil.
- Early detection of pupillary abnormalities can aid in managing diabetic complications.
Purpose:
- To investigate pupillary disorders in type II diabetes mellitus patients with autonomic neuropathy.
- To assess pupil diameter and response under mesopic, photopic, and pharmacologically dilated conditions.
Summary:
- Forty type II diabetic patients (subclinic retinopathy and nonproliferative diabetic retinopathy) and 20 controls were studied.
- Pupil diameters, constriction, and dilation ratios were measured using high-resolution infrared imaging.
- Significant differences were observed in mesopic and dilated pupil diameters, and constriction/dilation ratios between diabetic patients and controls (P < 0.05).
Impact:
- Pupillary measurements under different light and dilation conditions serve as reliable indicators of early autonomic neuropathy in type II diabetes.
- This non-invasive assessment can contribute to earlier diagnosis and management of diabetic complications.
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