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Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Testosterone replacement increases vasodilatory reserve in androgen-deficient female rats
Brian C Cooper1, Natalia I Gokina, George Osol
1Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, Vermont, USA. brian-cooper3825@hotmail.com <brian-cooper3825@hotmail.com>
Fertility and Sterility
|November 4, 2006
Abstract:
Testosterone replacement leads to increased coronary pressure-induced tone and vasodilatory reserve in oophorectomized rats. The mechanisms involve changes in endothelial nitric-oxide modulation of smooth-muscle constriction and are not a result of the peripheral conversion of T to estrogen.

