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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • The C Terminus Of The L-type Voltage-gated Calcium Channel Ca(v)1.2 Encodes A Transcription Factor.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • The C Terminus Of The L-type Voltage-gated Calcium Channel Ca(v)1.2 Encodes A Transcription Factor.

    • Related Experiment Videos

    The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor.

    Natalia Gomez-Ospina1, Fuminori Tsuruta, Odmara Barreto-Chang

    • 1Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA.

    Cell
    |November 4, 2006

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    A fragment of the L-type calcium channel (LTC) moves to the nucleus, acting as a transcription regulator. This CCAT protein influences gene expression, linking calcium channels directly to neuronal function and differentiation.

    Related Experiment Videos

    Area of Science:

    • Cellular Neuroscience
    • Molecular Biology
    • Gene Regulation

    Background:

    • Voltage-gated calcium channels are crucial for neuronal and muscle cell function.
    • The mechanisms linking calcium channels to nuclear gene expression remain unclear.

    Purpose of the Study:

    • To investigate the nuclear translocation and transcriptional role of voltage-gated calcium channel fragments.
    • To elucidate the function of the C-terminal fragment of Ca(V)1.2 in gene regulation.

    Main Methods:

    • Analysis of C-terminal fragment of Ca(V)1.2 (LTC) translocation to the nucleus.
    • Identification of nuclear binding partners and promoter interactions.
    • Assessment of CCAT's impact on endogenous gene expression.

    Main Results:

    • A C-terminal fragment of Ca(V)1.2, termed CCAT, translocates to the nucleus.
    • CCAT binds to nuclear proteins and endogenous promoters, regulating gene expression.
    • Nuclear localization of CCAT is developmentally regulated and calcium-dependent.

    Conclusions:

    • Voltage-gated calcium channels can directly regulate transcription via nuclear CCAT.
    • CCAT provides a mechanism linking calcium channel activity to neuronal function and differentiation.
    • This discovery opens new avenues for understanding excitable cell regulation.