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Updated: Jul 19, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
The potential role of computerized decision support systems to improve empirical antibiotic prescribing
1Health Informatics Centre, Division of Community Health Sciences, Mackenzie Building, Kirsty Semple Way, Dundee DD2 4BF, UK. p.g.davey@chs.dundee.ac.uk
Abstract:
Prudent antibiotic prescribing is a cornerstone of efforts to control the emergence and spread of antimicrobial resistance and to reduce the occurrence of Clostridium difficile associated diarrhoea, and is also currently the subject of a joint Working Party of the British Society for Antimicrobial Chemotherapy and the Hospital Infection Society. An article in this issue of the Journal describes a cluster randomized trial of an intervention to improve antibiotic prescribing using TREAT, a computerized decision support system. The results from this trial provide a significant contribution to the development of evidence-based prescribing of antibiotics.
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