Pregnancy-associated changes in the hemostatic system

Pregnancy, from implantation to parturition, presents unique and profound challenges to a women's hemostatic system. During pregnancy, potentially catastrophic bleeding can occur during implantation and endovascular trophoblast invasion of the maternal spiral arteries. The risk of hemorrhage reaches a peak during the third stage of labor when the placenta is shorn from the decidua basalis exposing 120 spiral arteries largely denuded of their smooth muscle, and thus, their ability to constrict in response to injury. These challenges are met by dramatic changes in the local uterine, and systemic hemostatic systems. The net effect of these changes is to increase the efficiency of clotting and to impair fibrinolysis. Unfortunately, they also lead to an increase in the prevalence of venous thromboembolism, which is otherwise uncommon in reproductive age women.