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Updated: Jul 19, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
Thrombophilia and placental pathology
1Department of Pathology, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA. raymond.redline@uhhs.com
Abstract:
Thrombophilic states have been associated with a variety of adverse pregnancy outcomes. The underlying placental pathology linking thrombophilia to these outcomes closely resembles that seen in other pregnancy disorders associated with chronic obstruction of the maternal or fetal vasculature. No single placental lesion is pathognomonic for thrombophilia. However, the finding of typical pathologic lesions in the context of recurrent pregnancy loss, severe early onset disease, or neonatal coagulation abnormalities should prompt the consideration of an underlying thrombophilic state.
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