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Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29).

W J Jordan1, J Eskdale, M Boniotto

  • 1Department of Oral Biology, New Jersey Dental School, Newark, NJ, USA.

Genes and Immunity
|November 4, 2006
PubMed
Summary
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Interferon lambda 1 (IFN-lambda1) activates monocytes and macrophages to produce IL-6, IL-8, and IL-10. This cytokine plays a key role in innate immune responses during viral infections.

Area of Science:

  • Immunology
  • Virology
  • Cytokine Biology

Background:

  • The interferon lambda (IFN-lambda) family, including IFN-lambda1/IL-29, are novel cytokines related to type-1 interferons and IL-10.
  • These cytokines are induced during viral infections and exhibit antiviral activity.

Purpose of the Study:

  • To investigate the capacity of IFN-lambda1 to modulate cytokine production by human immune cells.
  • To elucidate the role of IFN-lambda1 in innate immune responses.

Main Methods:

  • Exposure of whole peripheral blood mononuclear cells (PBMC) and purified monocyte/lymphocyte populations to IFN-lambda1.
  • Analysis of cytokine production (IL-6, -8, -10, TNF, IL-1) using stimulated cells.
  • Examination of IFN-lambda1 effects on low-level LPS-stimulated monocytes and human macrophages.

Related Experiment Videos

Main Results:

  • IFN-lambda1 specifically upregulated IL-6, IL-8, and IL-10 in PBMC in a dose-dependent manner.
  • Monocytes, not lymphocytes, were the primary IFN-lambda1-responsive cells, producing IL-6, IL-8, and IL-10.
  • IFN-lambda1 synergistically enhanced monocyte responses to low-level LPS and activated macrophages to produce these cytokines.

Conclusions:

  • IFN-lambda1 activates monocytes and macrophages, leading to the production of a specific set of cytokines (IL-6, -8, -10).
  • IFN-lambda1 is crucial for initiating innate immune responses at viral infection sites.