Related Experiment Video
Updated: Jul 19, 2026
12:43
On-Chip Endothelial Inflammatory Phenotyping
Published on: July 21, 2012
[Vascular adhesion protein-1 (VAP-1) in inflammatory process]
Małgorzata Pietruczuk1, Adam Pietruczuk, Joanna Zajkowska
1Oddział Intemistyczno-Kardiologiczny SP ZOZ w Sokółce. malpietr@piasta.pl
Przeglad Lekarski
|November 4, 2006
Summary
Vascular adhesion protein-1 (VAP-1) is key for leukocyte movement to inflammation sites. This review covers VAP-1 structure, function, and clinical applications.
Area of Science:
- Biochemistry
- Immunology
- Cell Biology
Context:
- Vascular adhesion protein-1 (VAP-1) is an endothelial cell surface molecule.
- VAP-1 mediates leukocyte adhesion and migration.
- Crucial role in inflammatory responses.
Purpose:
- To consolidate current knowledge on VAP-1.
- To detail its structure and biological functions.
- To explore VAP-1's clinical relevance and applications.
Summary:
- VAP-1, an adhesion molecule on endothelial cells, facilitates leukocyte recruitment.
- Its structure and enzymatic activity are critical for biological function.
- Clinical applications are emerging, particularly in inflammatory diseases.
Impact:
- Provides a comprehensive overview of VAP-1.
- Highlights VAP-1's significance in inflammation and immunity.
- Informs future research and therapeutic strategies targeting VAP-1.
Related Concept Videos
01:16Vascular Spasm
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
01:30Inflammatory Response I: Vascular and Cellular
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
01:25Acute Inflammation III: Local and Systemic Effects
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
01:38Inflammation
Overview
01:28Inflammation: Introduction
Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...