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Related Experiment Videos

Complexities in defining remission in rheumatic diseases.

T Pincus1, A Kavanaugh, D Aletaha

  • 1Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232-4500, USA. t.pinus@vanderbilt.edu

Clinical and Experimental Rheumatology
|November 7, 2006
PubMed
Summary

Defining remission in rheumatic diseases is complex, often requiring multiple measures instead of a single standard. Achieving and maintaining remission, especially in autoimmune conditions, may necessitate long-term therapy.

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • The rheumatology field increasingly focuses on remission due to understanding disease severity and new therapies.
  • Defining remission in rheumatic diseases is complex, unlike in many other conditions.

Purpose of the Study:

  • To explore the multifaceted nature of remission in rheumatic diseases.
  • To discuss the challenges and nuances in defining and achieving remission.

Main Methods:

  • Review of current understanding and literature on remission in rheumatology.
  • Analysis of the complexities in remission assessment and criteria.

Main Results:

  • Remission in rheumatic diseases lacks a single "gold standard," requiring multiple assessment measures.

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  • Spontaneous and drug-induced remission can be confused; remission may be transient.
  • Ongoing therapy is often needed indefinitely for autoimmune disease remission.
  • Patients with organ damage may be considered in remission if disease activity is controlled, despite persistent consequences.
  • Conclusions:

    • Achieving 100% remission may not always be feasible or necessary; "low disease activity" can be a practical goal.
    • The concept and definition of remission in rheumatic diseases remain subjects of ongoing discussion and research.