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Updated: Jul 19, 2026

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

Dalbavancin: a review for dermatologists.

Noah Scheinfeld¹

¹Department of Dermatology, St Lukes Roosevelt Hospital, New York, NY, USA. Scheinfeld@earthlink.net

Dermatology Online Journal

|November 7, 2006

Summary

Dalbavancin, a novel lipoglycopeptide antibiotic, demonstrated non-inferiority in treating complicated skin infections compared to standard treatments. Its once-weekly dosing offers potential benefits for patient care and infection reduction.

Area of Science:

Infectious Diseases
Pharmacology
Clinical Medicine

Background:

Complicated skin and skin structure infections (cSSSI) are often caused by Staphylococcus aureus (SA) and Streptococcus (SC).
Increasing antibiotic resistance, including methicillin-resistant SA (MRSA) and concerns over vancomycin-resistant SA (VRSA), necessitates new treatment options.
Dalbavancin is a novel lipoglycopeptide antibiotic developed to improve upon existing glycopeptides like vancomycin.

Purpose of the Study:

To evaluate the efficacy and safety of dalbavancin for treating complicated skin and skin structure infections (cSSSI).
To compare dalbavancin's non-inferiority against standard-of-care antibiotics for Gram-positive bacterial SSTIs.

Main Methods:

Phase-III clinical trials involving over 1,500 patients with skin and soft tissue infections (SSTIs).

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Evaluation of clinical response at 2 weeks post-therapy for dalbavancin compared to linezolid, cefazolin, or vancomycin.

Assessment of adverse effects associated with dalbavancin treatment.

Main Results:

Dalbavancin met the primary endpoint of non-inferiority compared to standard treatments.
The most common adverse effects reported were mild, including headache and pyrexia.
Once-weekly dalbavancin administration may reduce the need for continuous IV lines, potentially lowering infection rates.

Conclusions:

Dalbavancin shows promise as an effective treatment for Gram-positive bacterial cSSSI.
Its favorable side effect profile and convenient dosing schedule may enhance patient management and facilitate transitions to lower levels of care.
Further evaluation is needed to determine dalbavancin's role relative to vancomycin and other novel agents like linezolid.