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Updated: Jul 19, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
Published on: October 22, 2015
Psychoneuroendocrinology of anorexia nervosa
P Södersten1, C Bergh, M Zandian
1Section of Applied Neuroendocrinology, Mandometer Clinic, Karolinska Institutet, AB Mando, Novum, S-141 57 Huddinge, Sweden. per.sodersten@ki.se
Abstract:
It is suggested that the symptoms of anorexia nervosa are physiological responses to starvation. There is no evidence of a neural or non-neural dysfunction that predisposes women for anorexia nervosa and the endocrine and psychological consequences of starvation are reversed once patients have re-learnt how to eat and regained a normal body weight. Because variability in the supply of food may be a common evolutionary condition, it is more likely that body weight is variable than constant in normal circumstances. The role of the neuroendocrine system in times of feast and famine is to allow the individual to adopt behavioral strategies as needed rather than maintaining body weight homeostasis. Treatment of anorexic patients should aim at reducing their high level of physical activity in order to facilitate eating.
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