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Related Experiment Video

Updated: Jul 19, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
04:16

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Published on: August 5, 2021

Destination of titanium particles detached from titanium plasma sprayed implants.

M Franchi1, E Orsini, D Martini

  • 1Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore, Università di Bologna, Via Irnerio 48, 40126 Bologna, Italy. marco.franchi3@unibo.it

Micron (Oxford, England : 1993)
|November 7, 2006
PubMed
Summary

Small titanium particles from implants can migrate into surrounding bone and marrow tissue. Over time, smaller particles decrease significantly, suggesting dissolution and migration within the peri-implant environment.

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Tissue Engineering

Background:

  • Titanium plasma-sprayed (TPS) implants are widely used in orthopedic and dental applications.
  • Particle release from TPS implants during insertion is a potential concern.
  • Understanding the fate of these particles is crucial for assessing implant safety and efficacy.

Purpose of the Study:

  • To investigate the destination and behavior of titanium particles detached from TPS implants in the peri-implant bone and tissue.
  • To analyze the distribution and changes in titanium particles over time after implantation.

Main Methods:

  • Sheep tibiae were implanted with 24 TPS screws.
  • Samples were harvested at 14 and 90 days post-implantation.
  • Analysis was performed using light microscopy and scanning electron microscopy (SEM) with secondary and back-scattered electron imaging.

Main Results:

  • Detached titanium particles were found in both newly-formed bone matrix and marrow tissue.
  • Particles were more concentrated in marrow tissue than in bone matrix, decreasing by 66.4% over time.
  • Smaller particles (<250 µm²) showed an 81.5% decrease, suggesting dissolution, while larger particles remained stable. Particle migration towards distant tissues was observed.

Conclusions:

  • Detached titanium particles from TPS implants can disseminate within the peri-implant environment.
  • Smaller titanium particles appear to undergo dissolution and migration into marrow spaces.
  • Findings highlight the importance of considering particle behavior for long-term implant performance and patient outcomes.