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Published on: January 29, 2018
Bone mineral density in hip-fracture patients with Parkinson's disease: a case-control study
Marco Di Monaco1, Fulvia Vallero, Roberto Di Monaco
1Osteoporosis Research Center, Presidio Sanitario San Camillo, Torino, Italy. Merdici@h-sancamillo.to.it
Objective:
To investigate bone mineral density (BMD) levels in patients with Parkinson's disease (PD) who sustained a hip fracture.
Design:
Case-control study.
Setting:
Rehabilitation hospital in Italy.
Participants:
We investigated 831 out of 887 white patients consecutively admitted to a rehabilitation hospital because of an original hip fracture resulting from a fall. Twenty-eight (3.37%) of the 831 patients were affected by PD. Twenty-eight controls matched for sex, age, and hip-fracture type (cervical or trochanteric) were found among the 803 non-PD patients.
Interventions:
Not applicable.
Main Outcome Measures:
BMD was assessed by dual-energy x-ray absorptiometry (DXA) at the unfractured femur. Five sites were investigated in each subject: total proximal femur, femoral neck, trochanter, intertrochanteric area, and Ward's triangle. DXA scan was performed a mean +/- standard deviation of 22.2 +/- 7.8 days after fracture occurrence in the 28 patients and 22.0 +/- 5.3 days after fracture occurrence in the 28 controls.
Results:
BMD expressed as a T score did not differ significantly between the 28 PD patients and the 28 controls, whereas z score in the PD patients was significantly lower than 0 +/- 1 in the age- and sex-matched general population at 4 of the 5 sites of BMD assessment.
Conclusions:
A sample of PD fallers who sustained a hip fracture had femoral BMD levels similar to those found in matched hip-fracture fallers who did not suffer from PD and significantly lower than those found in the matched reference population.
