Related Experiment Video
Updated: Jul 19, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
Published on: June 15, 2017
Protein kinase C beta/early growth response-1 pathway: a key player in ischemia, atherosclerosis, and restenosis
Shi-Fang Yan1, Evis Harja, Martin Andrassy
1Division of Surgical Science, Department of Surgery, Columbia University, New York, New York 10032, USA. sy18@columbia.edu
Abstract:
Atherosclerosis, restenosis, and the consequences of ischemia are the major causes of morbidity and mortality worldwide. Elucidation of key contributing pathways in animal models of ischemia-reperfusion injury, atherosclerosis, and restenosis consequent to vascular injury may lead to great interest in determining if blocking these pathways could prevent vascular disease in human subjects. This review details the evidence that the protein kinase C (PKC) beta/early growth response-1 axis plays a central role in the response to both acute and chronic vascular stresses in animal models and also indicates the clinical implications of a specific inhibitor of PKCbeta, ruboxistaurin (LY333531).
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
cAMP-dependent Protein Kinase Pathways
PI3K/mTOR/AKT Signaling Pathway
MAPK Signaling Cascades
TGF - β Signaling Pathway
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...