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10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Intraabdominal complications after lung transplantation
C Brock Miller1, S Chris Malaisrie, Jateen Patel
1Department of Surgery, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA.
Journal of the American College of Surgeons
|November 7, 2006
Summary
Intraabdominal complications after lung transplantation significantly increase mortality. Early surgical intervention in these patients is associated with better survival rates, highlighting the need for prompt diagnosis and treatment.
Area of Science:
- Transplantation Surgery
- Gastroenterology
- Critical Care Medicine
Background:
- Nonpulmonary complications are a leading cause of morbidity and mortality in lung transplant recipients.
- Intraabdominal complications are particularly concerning due to the potential need for surgical intervention.
- Effective management of these complications is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the incidence and outcomes of intraabdominal complications following lung transplantation.
- To determine the impact of intraabdominal complications on patient mortality.
- To assess the effectiveness of operative versus non-operative management.
Main Methods:
- Retrospective review of 229 lung transplant recipients from January 1997 to December 2004.
- Analysis of 47 patients who developed intraabdominal complications, categorized as early (<30 days) or late (>30 days).
- Primary outcome variable was mortality; secondary outcomes included need for surgical intervention.
Main Results:
- 47 patients (20.5%) experienced intraabdominal complications, with 22 requiring surgical intervention.
- Five-year survival was significantly lower in patients with intraabdominal complications (34%) compared to those without (62%, p=0.01).
- Mortality was lower in patients treated operatively (9%) versus non-operatively (44%, p=0.02).
Conclusions:
- Intraabdominal complications after lung transplantation are associated with high mortality.
- Operative intervention for these complications is well-tolerated and linked to reduced mortality.
- A high index of suspicion and timely surgical intervention are essential for managing intraabdominal complications in lung transplant recipients.
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