Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cigarette smoke--an aging accelerator?

David Bernhard1, Christina Moser, Aleksandar Backovic

  • 1Vascular Biology Group, Division Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria. David.Bernhard@i-med.ac.at

Experimental Gerontology
|November 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current <i>in vitro</i> myocardial infarction co-culture models and their verification for clinical relevance.

Expert reviews in molecular medicine·2026
Same author

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients.

Scientific reports·2026
Same author

Air-Stable Cobalt-Semiquinone Radical Complexes on Carbon Nanotubes: A Redox Switch for Anion Response.

Journal of the American Chemical Society·2025
Same author

The Capability to Undergo ACSL4-Mediated Ferroptosis Is Acquired During Brown-like Adipogenesis and Affected by Hypoxia.

Cells·2025
Same author

Nanomechanical binding mechanism of ligands drives agonistic activity.

Nature communications·2025
Same author

Intrahospital Prevalence of Diabetes and Prediabetes in Medical Departments in Upper Austria.

Journal of clinical medicine·2025

Cigarette smoking accelerates aging, exhausting cellular defenses and leading to accumulated damage. This review links smoking chemicals to accelerated aging processes, reducing lifespan and disease-free life expectancy.

Area of Science:

  • Toxicology
  • Gerontology
  • Molecular Biology

Background:

  • Cigarette smoking significantly reduces lifespan and disease-free life expectancy.
  • The precise mechanisms linking smoking to disease and mortality remain incompletely understood.
  • Emerging evidence suggests smoking impairs cellular defense and repair functions, causing molecular damage.

Purpose of the Study:

  • To review and synthesize the evidence linking cigarette smoking to accelerated aging.
  • To propose a unifying principle that cigarette smoke chemicals accelerate aging processes.
  • To elucidate the mechanisms by which smoking impacts cellular health and longevity.

Main Methods:

  • Literature review of studies on smoking, cellular damage, and aging.
  • Analysis of biochemical pathways affected by cigarette smoke constituents.

Related Experiment Videos

  • Synthesis of evidence from toxicology, molecular biology, and gerontology.

    • Main Results:

    • Cigarette smoke chemicals deplete cellular defense and repair mechanisms.
    • Smoking leads to the accumulation of cellular damage, including mutations and protein dysfunction.
    • These molecular alterations are consistent with accelerated biological aging.

    Conclusions:

    • Cigarette smoking acts as a pro-aging agent, accelerating the biological aging process.
    • The deleterious health effects of smoking can be largely attributed to accelerated aging.
    • Understanding smoking as an aging accelerator may inform public health strategies and interventions.