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Updated: Jul 19, 2026

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
Published on: June 22, 2017
Basal ganglia oscillations and pathophysiology of movement disorders
Michal Rivlin-Etzion1, Odeya Marmor, Gali Heimer
1Department of Physiology, The Interdisciplinary Center for Neural Computation, The Hebrew University-Hadassah Medical School, Jerusalem, Israel, 91120.
Abstract:
Low frequency rest tremor is one of the cardinal signs of Parkinson's disease and some of its animal models. Current physiological studies and models of the basal ganglia differ as to which aspects of neuronal activity are crucial to the pathophysiology of Parkinson's disease. There is evidence that neural oscillations and synchronization play a central role in the generation of the disease. However, parkinsonian tremor is not strictly correlated with the synchronous oscillations in the basal ganglia networks. Rather, abnormal basal ganglia output enforces abnormal thalamo-cortical processing leading to akinesia, the main negative symptom of Parkinson's disease. Parkinsonian tremor has probably evolved as a downstream compensatory mechanism.
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