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Related Concept Videos

Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...

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Related Experiment Video

Updated: Jul 19, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

PGD for aneuploidy screening: an expensive hoax?

Patricio Donoso1, Paul Devroey

  • 1Centre for Reproductive Medicine, University Hospital, Vrije Universiteit Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium. pdonoso@alemana.cl

Best Practice & Research. Clinical Obstetrics & Gynaecology
|November 7, 2006
PubMed
Summary

Pre-implantation genetic diagnosis for aneuploidy screening (PGD-AS) shows limited benefit for improving in-vitro fertilization outcomes in specific patient groups. Further research is required before PGD-AS becomes standard clinical practice.

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Embryology

Background:

  • Pre-implantation genetic diagnosis for aneuploidy screening (PGD-AS) aims to enhance embryo selection in patients with poor in-vitro fertilization (IVF) outcomes.
  • High rates of numerical chromosome abnormalities in embryos contribute to IVF failure.
  • Existing studies on PGD-AS efficacy yield inconsistent results, hindering definitive conclusions.

Purpose of the Study:

  • To evaluate the effectiveness of PGD-AS in improving IVF outcomes across various patient populations.
  • To synthesize current evidence regarding PGD-AS performance in specific clinical scenarios.

Main Methods:

  • Review and analysis of existing randomized trials and observational studies on PGD-AS.
  • Assessment of PGD-AS impact on IVF success rates in different patient groups, including advanced maternal age, recurrent implantation failure, and recurrent miscarriage.

Main Results:

  • Randomized trials indicate PGD-AS does not improve outcomes for women of advanced age when unlimited embryo transfer is permitted.
  • In cases of recurrent implantation failure or miscarriage, PGD-AS primarily offers diagnostic information, particularly when only aneuploid embryos are identified.
  • The overall diagnostic value and clinical utility of PGD-AS remain under investigation.

Conclusions:

  • Current evidence does not support the routine implementation of PGD-AS for all IVF patients.
  • PGD-AS may provide diagnostic insights for specific patient cohorts, such as those with recurrent pregnancy loss.
  • More robust evidence is necessary to establish PGD-AS as a standard component of clinical IVF practice.