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Disruption of keratin intermediate filaments by ultraviolet radiation in cultured human keratinocytes
1Department of Microbiology, Boston University School of Medicine, MA 02118.
Photochemistry and Photobiology
|October 1, 1990
Abstract:
Fluorescence microscopy has been utilized to investigate the effects of UV irradiation on the organization of keratin intermediate filaments in normal human epidermal keratinocytes. Sun lamp irradiation induced the condensation of keratin intermediate filaments into the perinuclear region and inhibited the reorganization of keratin filaments normally induced by Ca2+. Exposure to UVC appeared to disrupt keratin filaments similarly, whereas UVA had no discernible effect.