Related Experiment Video
Updated: Jul 19, 2026
09:23
Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
Published on: June 16, 2015
ArteFill: a third-generation permanent dermal filler and tissue stimulator
Gottfried Lemperle1, Stefania de Fazio, Pierre Nicolau
1Division of Plastic Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8890, USA. glemperle@aol.com
Clinics in Plastic Surgery
|November 7, 2006
Summary
Newer polymethylmethacrylate (PMMA) dermal fillers like ArteFill have improved safety profiles. ArteFill microspheres meet FDA standards, potentially reducing granuloma rates further than Artecoll.
Area of Science:
- Dermatology
- Biomaterials Science
Background:
- Previous polymethylmethacrylate (PMMA) dermal fillers had technical and physiological limitations.
- Polymethylmethacrylate (PMMA) microspheres are used in dermal filler technology.
Purpose of the Study:
- To evaluate the improved safety and efficacy of third-generation PMMA dermal fillers.
- To compare the particle size distribution of ArteFill to FDA standards.
Main Methods:
- Analysis of PMMA microsphere size distribution in ArteFill.
- Review of clinical experience with Artecoll and ArteFill.
Main Results:
- ArteFill PMMA microspheres meet the FDA's new limit for particles under 20 micrometers.
- Artecoll and ArteFill have demonstrated safety, predictability, and effectiveness in author experience.
- A further reduction in granuloma rates is anticipated with ArteFill compared to Artecoll.
Conclusions:
- Third-generation PMMA dermal fillers represent a significant improvement over earlier versions.
- ArteFill is expected to offer an enhanced safety profile for dermal filler applications.
- FDA approval and international marketing of ArteFill were anticipated.
