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The expression of matrix metalloproteinase-11 protein in various types of glomerulonephritis

Lydia Nakopoulou1, Andreas C Lazaris, Ioannis Boletis

  • 1Department of Pathology, The Athens National University Medical School, 75 Mikras Asias str., Goudi, GR-115 27 Athens, Greece. lnakopou@cc.uoa.gr

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|November 7, 2006
PubMed
Abstract

Insights

Matrix metalloproteinase-11 (MMP-11) is present in diseased glomeruli and may attract macrophages, suggesting an inflammatory role. MMP-11 expression does not appear to promote proliferation or fibrosis in these kidney conditions.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Matrix metalloproteinases (MMPs) are crucial in tissue remodeling and inflammation.
  • Metalloproteinase-11 (MMP-11) is linked to tissue remodeling processes.
  • Understanding MMP-11's role in glomerulonephritis is essential for comprehending kidney disease pathogenesis.

Purpose of the Study:

  • To investigate the expression of MMP-11 protein in various types of glomerulonephritis.
  • To elucidate the functional role of MMP-11 expression in diseased glomeruli.

Main Methods:

  • Immunohistochemistry was used to analyze MMP-11 expression in 95 renal biopsies.
  • Biopsies included primary glomerulonephritis, lupus-associated, and ANCA-associated glomerulonephritis.
  • Cell proliferation (Ki67) and macrophage presence (CD68) were assessed.

Main Results:

  • MMP-11 immunopositivity was detected in most pathological glomeruli, notably in ANCA-associated glomerulonephritis.
  • MMP-11 expression correlated with sclerosis, microadhesions, and crescents, but not with fibrotic areas.
  • MMP-11 immunoreactivity was associated with increased mesangial macrophages (P = 0.001) but not proliferating cells (P = 0.170).

Conclusions:

  • MMP-11 may act as an inflammatory mediator, attracting macrophages to the mesangium.
  • MMP-11 is unlikely to have significant mitogenic or antifibrotic effects in glomerulonephritis.

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