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Selectins

Selectins

Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...

Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...

Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

Anchoring Junctions

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...

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Related Experiment Video

Updated: Jul 19, 2026

Quantitation of Endothelial Cell Adhesiveness In Vitro

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

Cell-cell adhesion in lung endothelium.

D Michael Shasby¹

¹Dept. of Internal Medicine, University of Iowa College of Medicine, 140E EMRB, Iowa City, IA 52242, USA. michael-shasby@uiowa.edu

American Journal of Physiology. Lung Cellular and Molecular Physiology

|November 7, 2006

Summary

Homotypic cell-cell adhesion is vital for lung function. This review highlights key adhesion molecules specific to lung endothelium, addressing knowledge gaps in pulmonary and bronchial circulations.

Area of Science:

Cell Biology
Physiology
Pulmonary Medicine

Background:

Homotypic cell-cell adhesion is crucial for tissue development, regeneration, and function.
Knowledge of endothelial cell-cell adhesion molecules is less extensive than for epithelial counterparts.
Specific adhesion molecules in lung endothelium remain largely uncharacterized.

Purpose of the Study:

To review homotypic cell-cell adhesion molecules in lung endothelium.
To identify molecules important for pulmonary and bronchial circulations.
To address the limited understanding of endothelial adhesion in the lung.

Main Methods:

Literature review focused on endothelial cell-cell adhesion.
Analysis of studies concerning pulmonary and bronchial circulations.

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Quantitative In vitro Assay to Measure Neutrophil Adhesion to Activated Primary Human Microvascular Endothelial Cells under Static Conditions

Quantitative In vitro Assay to Measure Neutrophil Adhesion to Activated Primary Human Microvascular Endothelial Cells under Static Conditions

Published on: August 23, 2013

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Last Updated: Jul 19, 2026

Quantitation of Endothelial Cell Adhesiveness In Vitro

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

Quantitative In vitro Assay to Measure Neutrophil Adhesion to Activated Primary Human Microvascular Endothelial Cells under Static Conditions

Quantitative In vitro Assay to Measure Neutrophil Adhesion to Activated Primary Human Microvascular Endothelial Cells under Static Conditions

Published on: August 23, 2013

Identification of molecules with potential roles in lung endothelium.

Main Results:

Epithelial adhesion molecules are better understood than endothelial ones.
Few adhesion molecules are specifically identified for lung endothelium.
Several homotypic adhesion molecules are likely important in lung endothelium.

Conclusions:

Understanding lung endothelial adhesion is critical for pulmonary health.
Further research is needed to fully elucidate the role of specific adhesion molecules.
This review consolidates current knowledge and identifies future research directions.