Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developing and evaluating genomics- or proteomics-based diagnostic tests: statistical perspectives.

Xuejun Peng1

  • 1Department of Quantitative Health Sciences, The Cleveland Clinic Foundation, OH, USA.

Methods in Molecular Medicine
|November 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gauging lipid vulnerabilities in mRNA-LNPs under various environmental stressors through TIMS-TOF analysis.

RSC advances·2026
Same author

Longitudinal Plasma Multiomics Characterization of Nephrotoxicity in Beagles Following Repeated Dosing of Enteric-Coated Propyl Gallate Tablets.

ACS pharmacology & translational science·2025
Same author

Synthesis and Evaluation of diaryl ether modulators of the leukotriene A<sub>4</sub> hydrolase aminopeptidase activity.

European journal of medicinal chemistry·2024
Same author

Efficient removal of tetracycline hydrochloride through novel Fe/BiOBr/Bi<sub>2</sub>WO<sub>6</sub> photocatalyst prepared by dual-strategy under visible-light irradiation.

Journal of environmental sciences (China)·2023
Same author

Metabolomic Profiling of Human Urine Samples Using LC-TIMS-QTOF Mass Spectrometry.

Journal of the American Society for Mass Spectrometry·2021
Same author

The application of 3D printed surgical guides in resection and reconstruction of malignant bone tumor.

Oncology letters·2017

Genomics and proteomics offer powerful tools for early disease diagnosis and prognosis. Rigorous statistical methods are essential for translating these molecular tests from research to clinical practice, ensuring reliability and efficacy.

Area of Science:

  • Genomics and Proteomics
  • Translational Medicine
  • Biostatistics

Background:

  • The Human Genome Project and subsequent genome sequencing initiatives have spurred advancements in genetics technologies.
  • High-throughput genomics and proteomics are increasingly applied in clinical and pharmacological research.
  • Molecular alterations often precede clinical symptoms, offering potential for early disease detection and prognosis.

Purpose of the Study:

  • To discuss statistical considerations for developing reliable and clinically meaningful genomics- or proteomics-based diagnostic and prognostic tests.
  • To highlight the importance of rigorous standards for translating molecular tests from research ('bench') to clinical application ('bed').

Main Methods:

  • The chapter focuses on statistical considerations crucial for the development process.

Related Experiment Videos

  • Emphasis is placed on study design, appropriate statistical analyses, and valid assessment of clinical efficacy.

    • Main Results:

    • Successful attempts at molecular diagnosis or prognosis using genomics/proteomics have been published.
    • However, translation to clinical practice requires adherence to stringent standards.

    Conclusions:

    • Developing clinically useful genomics- and proteomics-based tests necessitates robust statistical methodologies.
    • Sound study design and rigorous validation are paramount for successful clinical translation and application.