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Related Experiment Video

Updated: Jul 19, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Quantitative assay for mouse atherosclerosis in the aortic root.

Julie Baglione1, Jonathan D Smith

  • 1Department of Cell Biology, The Cleveland Clinic Foundation, OH, USA.

Methods in Molecular Medicine
|November 7, 2006
PubMed
Summary

This study details methods for measuring aortic root lesion area in mice, a key technique for studying atherosclerosis. Accurate quantification aids research into cardiovascular disease models.

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Area of Science:

  • Cardiovascular Research
  • Animal Models of Human Disease
  • Atherosclerosis Research

Background:

  • Mice are crucial for genetic disease modeling, particularly for human conditions.
  • Studying atherosclerosis in mice often involves genetic modifications or specific diets.
  • Assessing atherosclerosis in mice is vital for understanding disease mechanisms.

Purpose of the Study:

  • To provide detailed, reproducible methods for quantifying mouse aortic root lesion area.
  • To standardize a commonly used medium-throughput technique for atherosclerosis research.
  • To facilitate histological examination and analysis of atherosclerotic lesions in mouse models.

Main Methods:

  • Detailed protocols for the quantitative analysis of mouse aortic root lesion area.

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Last Updated: Jul 19, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
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Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Published on: February 14, 2025

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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

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  • Focus on measurement techniques for histological examination of lesions.
  • Standardization of a medium-throughput assessment method.

    • Main Results:

    • Established detailed methods for quantitative analysis of mouse aortic root lesion area.
    • Provided a framework for consistent and accurate histological assessment.
    • Enabled reliable measurement of atherosclerosis in mouse models.

    Conclusions:

    • Quantitative analysis of aortic root lesion area is a valuable method in atherosclerosis research.
    • Standardized methods improve the reliability and comparability of mouse model studies.
    • This protocol supports the study of factors influencing atherosclerosis susceptibility in mice.