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[DNA cytometry in gastric cancer--a comparison between static cytometry on cytologic and histologic preparations and
Verhandlungen Der Deutschen Gesellschaft Fur Pathologie
|January 1, 1990
Abstract:
Static cytometry on cytologic and histologic preparations and flow cytometry are the basic techniques of DNA cytometry with certain advantages and drawbacks. An exact and reliable assessment of DNA ploidy and stem line heterogeneity of paraffin-embedded specimens is best performed with static cytometry on smears. The high resolution of DNA histograms in flow cytometry is reduced by the often strong portion of detritus and therefore the internal reference peak or small tumor stem lines might not be identified. The use of histologic preparations is advantageous for the analysis of correlations between histomorphologic tumor heterogeneity and stem line heterogeneity.