[Histomorphometric study of normal, atypical and neoplastic pancreatic duct epithelium]

Morphometric and densitometric measurements were applied to nuclei of normal, atypical (incl. hyperplastic) and neoplastic pancreatic duct epithelium in cases of inconspicuous pancreas, chronic pancreatitis and carcinomatous pancreas. These datas and their central moments and medians were used in linear discriminant analysis. A gradual shift of nuclear size and deviation from spherical form results in normal epithelium from normal pancreas to chronic pancreatitis and to carcinomatous pancreas. The atypical or hyperplastic epithelium has denser caryoplasma in chronic pancreatitis than in carcinomatous pancreas.