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[Immunophenotypic and genotypic characterization of T-cell populations in thymomas]
C C Scherrer1, H Knecht, M Wiesli
1Institut für Pathologie, Universität Zürich.
Verhandlungen Der Deutschen Gesellschaft Fur Pathologie
|January 1, 1990
Abstract:
The T cell component of eight thymomas has been studied by immunohistochemistry and Southern blot analysis. In the cortical areas of thymomas the T cells expressed an immature cortical phenotype. In cortical and medullary areas T cell Receptor (TcR) alpha-beta lymphocytes heavily predominated over TcR gamma-delta lymphocytes. No genomic rearrangement of TcR and Immunoglobulin genes could be detected, thus supporting the non neoplastic nature of the lymphocyte component in thymomas.