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Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Jul 19, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

[Sinonasal mucosal malignant melanoma].

Patrick Saint-Blancard1, Michel Kossowski2

  • 1Service d'anatomie pathologique, Hôpital d'Instruction des Armées Percy, Clamart (92).

Presse Medicale (Paris, France : 1983)
|November 7, 2006
PubMed
Summary

Primary sinonasal malignant melanomas are rare and often misdiagnosed. Early detection is crucial for improving the prognosis of these uncommon mucosal tumors.

Area of Science:

  • Oncology
  • Pathology

Background:

  • Mucosal melanomas are rare, with sinonasal malignant melanomas being particularly uncommon and prone to misclassification.
  • Differential diagnosis must exclude other sinonasal malignancies such as carcinoma, lymphoma, sarcoma, and olfactory neuroblastoma.

Observation:

  • Two cases of sinonasal melanoma are presented: a 68-year-old man with a right nasal cavity tumor initially managed for chronic sinusitis, and a 77-year-old woman with osteolytic growth in the left maxillary sinus presenting as gingival swelling.

Findings:

  • Pathologic examination of biopsy samples confirmed sinonasal malignant melanomas in both cases.
  • Histological diagnosis is challenging due to the tumor's polymorphic features, underscoring the importance of immunohistochemical studies.

Implications:

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Last Updated: Jul 19, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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  • The inaccessibility of sinonasal mucosa for self-examination contributes to delayed diagnosis and poor prognosis.
  • Increased awareness and accurate diagnostic methods are essential for timely intervention in sinonasal melanoma cases.