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[Immunohistologic photometric quantification of pyruvate kinase content of rat tumors]
R Bahnemann1, M Domingo, E Eigenbrodt
1Abteilung Pathologie, BASF AG, Ludwigshafen.
Verhandlungen Der Deutschen Gesellschaft Fur Pathologie
|January 1, 1990
Abstract:
86 benign and malignant tumours were investigated histologically and immunohistologically. Staining intensity was measured by scanning-photometry. The computed optical density was digitalized and evaluated with an image analysis system. The results indicate a significantly higher amount of M2-PK in malignant tumours. In the adenocarcinomas of the mammary gland, the content of the M2-PK increased parallel with malignancy (p less than 0.01; r = 0.743). The M2-PK can serve as an indicator of the grade of malignancy in mammary tumours of the rat.