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Related Concept Videos

Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation - insights from acute and chronic electroanatomic remapping in the randomized SINGLE-SHOT CHAMPION trial.

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Related Experiment Video

Updated: Jul 19, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Cardiac resynchronization therapy in chronic heart failure.

Christian Sticherling1, Beat Schaer, Martin Coenen

  • 1University Hospital Basel, Division of Cardiology, Basel, Switzerland. csticherling@uhbs.ch

Swiss Medical Weekly
|November 7, 2006
PubMed
Summary

Cardiac resynchronization therapy (CRT) improves outcomes for heart failure patients with dyssynchrony. Identifying non-responders remains a challenge for this effective treatment.

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Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
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Published on: April 11, 2025

Implantation of Total Artificial Heart in Congenital Heart Disease
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Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

Related Experiment Videos

Last Updated: Jul 19, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
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Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

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Implantation of Total Artificial Heart in Congenital Heart Disease
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Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Severe, drug-refractory heart failure with intraventricular dyssynchrony affects many patients.
  • Optimized medical therapy alone has limitations in improving outcomes.
  • Cardiac resynchronization therapy (CRT) offers a potential therapeutic option.

Purpose of the Study:

  • To review the efficacy of CRT in heart failure patients.
  • To discuss challenges in patient selection for CRT.
  • To explore uncertainties surrounding CRT application.

Main Methods:

  • Review of clinical trial data on CRT efficacy.
  • Discussion of patient selection criteria and non-responder identification.
  • Exploration of specific patient subgroups and device considerations.

Main Results:

  • CRT has demonstrated significant reductions in mortality.
  • Improvements in symptoms, exercise tolerance, and left ventricular function were observed.
  • A notable percentage of patients with bundle branch block do not respond to CRT.

Conclusions:

  • CRT is a valuable therapy for selected heart failure patients.
  • Accurate patient selection is crucial for maximizing CRT benefits.
  • Further research is needed to address uncertainties in CRT application, including atrial fibrillation and defibrillator roles.