Outcome of percutaneous coronary intervention in HIV-infected patients

Amit Segev1, Warren J Cantor, Bradley H Strauss

  • 1The Roy and Ann Foss Interventional Cardiology Research Program, Terrence Donnelly Heart Center, St Michael's Hospital, Toronto, Ontario, Canada.

Insights

Percutaneous coronary interventions (PCI) in HIV-infected patients show poor long-term outcomes. Routine use of drug-eluting stents is recommended for this high-risk group.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Interventional Cardiology

Background:

  • Human Immunodeficiency Virus (HIV) infection is associated with increased cardiovascular risk.
  • Understanding the outcomes of cardiovascular interventions in HIV-infected patients is crucial.

Purpose of the Study:

  • To evaluate the long-term outcomes of percutaneous coronary interventions (PCI) in patients with HIV infection.
  • To determine the efficacy and safety of PCI in this specific patient population.

Main Methods:

  • Retrospective analysis of 12 HIV-infected patients who underwent PCI.
  • Assessment of clinical and angiographic outcomes, including mortality, restenosis, and symptom recurrence.

Main Results:

  • High rates of adverse events were observed, including two deaths from HIV-related infections.
  • Seven patients experienced severe restenosis or angina, necessitating further interventions.
  • Only three patients remained symptom-free at long-term follow-up.

Conclusions:

  • HIV-infected patients represent a high-risk group for PCI.
  • Routine use of drug-eluting stents is recommended to improve outcomes in these patients.

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...