The biocompatibility testing of some dental amalgams in vivo

The biological responses to some dental amalgams were determined in vivo and compared with those of dental porcelain. The technique of implantation employed in the study addressed some of the vagaries of the Recommended Standard Practices for Biological Evaluation of Dental Materials (RSP) and considered both cellular responses (inflammation, infiltration and fibrogenic cell activity) and the organizational status of the resultant encapsulation. The implantation sites for both the experimental and control were biogeometrically similar, unlike those currently recommended in RSP. At the end of the test period, all the dental amalgams tested caused minor responses reflected by the formation of thin capsules with an acceptable matrix organization. The Australian manufactured dental amalgams--Permite C, Lojic, F400, New Ultrafine and GS80 all produced even capsules with quiescent cells. By one hundred days, the capsule around Dispersalloy, although generally well formed, showed some areas of cellular activity and matrix variability. The biological responses to all the dental amalgams examined were mild and considered to be acceptable for clinical usage. The matrix organization of enveloping capsules must be considered in the determination of the biocompatibility of a dental restorative material.