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Correlation between fibrinogen level and cerebral infarction

Yi-cheng Zhu1, Li-ying Cui, Bao-lai Hua

  • 1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730. zhuych910@yahoo.com.cn

Chinese Medical Sciences Journal = Chung-Kuo I Hsueh K'O Hsueh Tsa Chih
|November 8, 2006
PubMed

Insights

Elevated plasma fibrinogen levels are linked to cerebral infarction (CI) and its subtypes. Persistent high fibrinogen after stroke indicates a continued risk factor for CI.

Area of Science:

  • Neurology
  • Hematology
  • Cardiovascular Research

Background:

  • Cerebral infarction (CI) is a leading cause of disability and mortality worldwide.
  • Plasma fibrinogen, a key protein in coagulation, has been implicated in thrombotic events.
  • Understanding the role of fibrinogen in CI pathogenesis is crucial for risk stratification and management.

Purpose of the Study:

  • To examine the association between plasma fibrinogen levels and the occurrence of cerebral infarction (CI).
  • To investigate potential differences in fibrinogen levels across various subtypes of cerebral infarction.
  • To explore the correlation of fibrinogen with atherosclerosis in different vascular beds.

Main Methods:

  • A case-controlled study involving 131 patients with CI and 148 healthy controls.
  • Plasma fibrinogen levels were quantified using the Clauss method.
  • Statistical analysis included correlation and odds ratio calculations.

Main Results:

  • High plasma fibrinogen levels at CI onset (3.09 g/L) were significantly associated with the disease (OR = 2.47).
  • Persistent elevated fibrinogen at 6 months post-stroke (3.14 g/L) remained a strong predictor of CI (OR = 4.34).
  • Higher fibrinogen levels correlated with total anterior circulation infarction (TACI), partial anterior circulation infarction (PACI), and posterior circulation infarction (POCI), as well as extracranial atherosclerosis.

Conclusions:

  • Plasma fibrinogen may serve as a significant risk factor for cerebral infarction.
  • Fibrinogen levels appear to correlate with specific CI subtypes and the presence of extracranial atherosclerosis.
  • Further research is warranted to elucidate the precise mechanisms linking fibrinogen to CI and atherosclerosis.
Abstract

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