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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
08:56

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Published on: November 7, 2014

Gait variability in people with multiple sclerosis.

S J Crenshaw1, T D Royer, J G Richards

  • 1Department of Health, Nutrition, and Exercise Sciences, University of Delaware, Newark, DE, 19716, USA. sjcren@udel.edu

Multiple Sclerosis (Houndmills, Basingstoke, England)
|November 8, 2006
PubMed
Summary

Patients with multiple sclerosis (MS) exhibit greater kinematic gait variability than healthy individuals. Fatigue did not significantly alter gait variability in MS patients, highlighting the need to consider baseline variability in treatment studies.

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Area of Science:

  • Neurology
  • Biomechanics
  • Rehabilitation Science

Background:

  • Multiple sclerosis (MS) presents with diverse symptoms, impacting functional mobility.
  • Understanding gait variability is crucial for assessing treatment efficacy in MS.
  • Fatigue is a common symptom in MS, potentially affecting motor performance.

Purpose of the Study:

  • To investigate within-day and between-day changes in gait variability.
  • To compare gait variability in fresh versus fatigued states for MS patients.
  • To establish a baseline for meaningful change in MS treatment research.

Main Methods:

  • Gait parameters were measured in 20 MS patients and 8 healthy controls.
  • Variability was quantified using standard deviations of kinematic and kinetic variables.
  • A two-way ANOVA analyzed group and condition effects on variability.

Main Results:

  • MS patients demonstrated significantly higher hip, knee, and ankle kinematic variability compared to controls.
  • No significant differences in variability were found between fresh and fatigued conditions for MS patients.
  • Kinetic variability did not differ between groups or conditions; MS patients walked slower and reported more fatigue.

Conclusions:

  • MS patients exhibit increased kinematic gait variability, independent of fatigue levels.
  • Baseline kinematic gait variability should be considered when evaluating interventions for MS.
  • Future research should account for heightened variability in MS to accurately measure treatment effects.