Related Experiment Video
Updated: Jul 19, 2026

Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction
Published on: April 10, 2026
IOTN (DHC): is it supported by evidence?
1Walsall Manor Hospital, Moat Road, Walsall WS2 9PS, UK.
Unlabelled:
The strength of the evidence linking some common malocclusion traits (which are used as the basis for IOTN classification) with dental disease is reviewed. It is concluded that IOTN is not a reliable predictor of the potential impact of malocclusion on future dental health, and that alternative indices, which place greater emphasis on the aesthetic impairment and take account of patient perceptions, are more appropriate for assessing an individual's orthodontic treatment need.
Clinical Relevance:
IOTN is likely to assume greater significance with the advent of the new GDS/PDS regulations pertaining to orthodontics. However, all practitioners, including those who commission specialist services, should be aware of its limitations, especially in relation to the Dental Health Component.
Related Concept Videos
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Heart Failure VI: Adjunct Therapies
Nursing Diagnosis
The nursing diagnosis focuses on evidence-based...
Cardiomyopathy II: Dilated Cardiomyopathy
