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Updated: Jul 19, 2026
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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
Advanced glycation end products and vascular structure and function
Georgia Soldatos1, Mark Emmanuel Cooper
1Baker Medical Research Institute, Melbourne, Victoria 8008, Australia. Georgia.Soldatos@baker.edu.au
Current Hypertension Reports
|November 8, 2006
Summary
Advanced glycation end products (AGEs) contribute to diabetes complications like atherosclerosis and arterial stiffness. Targeting AGEs may offer future treatments for vascular disease and hypertension in diabetic patients.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Metabolic Diseases
Background:
- Diabetes mellitus is a global epidemic causing microvascular and macrovascular complications.
- Metabolic derangement in diabetes leads to chronic tissue injury.
- Vascular complications in diabetes have multiple proposed pathophysiologic mechanisms.
Purpose of the Study:
- To review the role of advanced glycation end products (AGEs) in diabetic atherosclerosis.
- To examine the contribution of AGEs to arterial stiffness in diabetes.
- To discuss potential pharmacologic interventions targeting AGEs.
Main Methods:
- Literature review focusing on advanced glycation end products (AGEs).
- Analysis of the role of AGEs in diabetes-associated atherosclerosis.
- Examination of AGEs' impact on arterial stiffness.
Main Results:
- Advanced glycation end products (AGEs) are implicated in the pathogenesis of diabetes-associated atherosclerosis.
- Higher levels of AGEs correlate with increased prevalence of arterial stiffness.
- AGEs contribute to chronic tissue injury and vascular complications in diabetes.
Conclusions:
- Advanced glycation end products (AGEs) play a significant role in diabetes-related vascular complications.
- Interventions targeting AGEs show promise for treating atherosclerosis and hypertension in diabetic individuals.
- Further research into AGEs' mechanisms and therapeutic targeting is warranted.
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