Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Microtubule Instability02:17

Microtubule Instability

Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated assembly and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient experience with endoscopic ultrasound and magnetic resonance cholangiopancreatography for pancreatic cancer screening (The PATRIOT study).

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2026
Same author

Psychosocial Impact of Endoscopic Procedural Complications on Gastroenterologists: The Second Victims.

Gastroenterology·2025
Same author

A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer.

eLife·2024
Same author

Cholangioscopy as a rescue for a post-cholecystectomy adherent stone formed around a migrated surgical clip in the common bile duct.

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy·2024
Same author

Submucosal tunneling endoscopic full-thickness resection for management of a rare case of esophageal GI stromal tumor.

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy·2024
Same author

Disparities in race, ethnicity, sex, and age inclusion in pancreatic cancer screening studies: a systematic review and meta-analysis.

Gastrointestinal endoscopy·2024

Related Experiment Video

Updated: May 7, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 29, 2010

Microsatellite instability in interval colon cancers.

Mandeep S Sawhney1, William D Farrar, Srivani Gudiseva

  • 1Section of Gastroenterology, Minneapolis VA Medical Center, Minneapolis, Minnesota 55417, USA. sawhn001@umn.edu

Gastroenterology
|November 8, 2006
PubMed
Summary
This summary is machine-generated.

Interval colon cancers are nearly four times more likely to show microsatellite instability (MSI), indicating a link to mismatch repair gene dysfunction. This finding suggests rapid tumor growth may explain some interval colon cancers.

More Related Videos

Quantification of Colonic Stem Cell Mutations
07:53

Quantification of Colonic Stem Cell Mutations

Published on: September 25, 2015

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Related Experiment Videos

Last Updated: May 7, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 29, 2010

Quantification of Colonic Stem Cell Mutations
07:53

Quantification of Colonic Stem Cell Mutations

Published on: September 25, 2015

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Area of Science:

  • Gastroenterology and Oncology
  • Molecular Biology and Genetics

Background:

  • Colon cancers detected after a complete colonoscopy may arise from "failure of colonoscopy" or rapid tumor growth.
  • Tumors associated with mismatch repair gene pathway loss exhibit rapid growth.
  • Microsatellite instability (MSI) is a hallmark of mismatch repair gene deficiency.

Purpose of the Study:

  • To investigate if interval colon cancers are more frequently linked to loss of mismatch repair gene function.
  • To determine if interval colon cancers exhibit higher rates of microsatellite instability (MSI) compared to noninterval cancers.

Main Methods:

  • A case-control study identified interval colon cancers (diagnosed within 5 years post-colonoscopy) and noninterval cancers.
  • Interval cancers were frequency-matched to noninterval cancers by age and sex.
  • Archived tumor specimens were tested for microsatellite instability (MSI).

Main Results:

  • Microsatellite instability (MSI) was detected in 30.4% of interval cancers versus 10.3% of noninterval cancers (P = .003).
  • Interval cancers were 3.7 times more likely to exhibit MSI than noninterval cancers after age adjustment.
  • The association between interval cancers and MSI was strongest for distal colon tumors (OR, 17.5; P = .008).

Conclusions:

  • Interval colon cancers show a significantly higher association with mismatch repair gene dysfunction.
  • Microsatellite instability (MSI) is a key factor in the development of a substantial proportion of interval colon cancers.
  • These findings suggest rapid tumor progression due to genetic instability contributes to interval colon cancers.