Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An exciting release on TRPM7.

Craig Montell1

  • 1Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Neuron
|November 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The HOST assay: an automated video-based evaluation of mosquito attraction to thermal infrared.

Nature protocols·2026
Same author

Gustatory avoidance of fatty acids by <i>Aedes aegypti</i> depends on an arthropod-specific TRP channel.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The sensory arsenal mosquitoes use to find us.

Trends in parasitology·2025
Same author

Control of odor sensation by light and cryptochrome in the <i>Drosophila</i> antenna.

iScience·2025
Same author

Cholesterol taste avoidance in <i>Drosophila melanogaster</i>.

eLife·2025
Same author

Visual threat avoidance while host seeking by Aedes aegypti mosquitoes.

Cell reports·2025

Synaptic vesicles may not release all neurotransmitters. TRPM7 channels on vesicles are essential for releasing acetylcholine, suggesting TRPM7 supplies counterions for neurotransmitter release.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Ion Channels

Background:

  • Synaptic vesicles store and release neurotransmitters, but complete release is not guaranteed.
  • A model proposes neurotransmitter release requires counterion entry into vesicles.
  • The identity of the channel facilitating counterion movement has remained elusive.

Discussion:

  • Krapivinsky et al. identified TRPM7 channels localized to synaptic vesicles.
  • TRPM7 is crucial for the release of the positively charged neurotransmitter, acetylcholine.
  • This finding implicates TRPM7 as the potential counterion channel.

Key Insights:

  • TRPM7 ion channel is present on synaptic vesicles.
  • TRPM7 function is necessary for acetylcholine release.

Related Experiment Videos

  • TRPM7 may be the long-sought channel for counterion-mediated neurotransmitter release.

    • Outlook:

    • Further research can elucidate the precise mechanism of TRPM7 in counterion transport.
    • Understanding TRPM7's role could offer new therapeutic targets for neurological disorders.
    • This discovery opens new avenues for studying synaptic transmission regulation.