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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
[Necrotizing cellulitis complicating varicella in two children given nonsteroidal anti-inflammatory drugs]
M-L Louis1, F Launay, J-M Guillaume
1Service de Chirurgie Infantile, Hôpital Nord, chemin des Bourrelys, 13915 Marseille Cedex 20. louis.marie-laure@neuf.fr
Abstract:
We report two cases of fasciitis with necrotizing hypodermitis of the foot and arm which complicated varicella in immunocompetent children given nonsteroidal anti-inflammatory drugs. The skin barrier and immune function are weakened by the varicella zoster virus. Exposure to nonsteroidal anti-inflammatory drugs further favors necrotizing cutaneous infections caused by group A beta hemolytic streptococci. MRI can confirm the presence of superficial aponevrosis necrosis defining necrotizing fasciitis but should not retard surgical management which is always indicated for necrotizing fasciitis and sometimes for necrotizing dermo-hypodermitis.
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