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Updated: Jul 19, 2026

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
Published on: May 9, 2025
Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa
G Piazzi1, P Paterini, C Ceccarelli
11Centre of Applied Biomedical Research (CRBA), S Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy. giulia.piazzi@yahoo.it
Abstract:
The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.
