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Published on: March 14, 2019
Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage
Stefania Gelmini1, Melissa Poggesi, Pamela Pinzani
1Clinical Biochemistry Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy.
Abstract:
We tested Tankyrase-1 mRNA expression in colon cancer patients to evaluate the prognostic role of this parameter by real-time RT-PCR in a retrospective group of 82 unselected patients with colon cancer. Paired cancer and corresponding not affected tissues were used. Laser-assisted microdissection was used to measure Tankyrase-1 mRNA in homogeneous cancer cell populations and in normal colon epithelium of the same patients. Tankyrase-1 mRNA in colon cancers, as a mean, was significantly higher than in paired not affected tissues (p<0.0001), but its level correlates inversely with a cancer progression stage. Survival analysis indicated that lower Tankyrase-1 mRNA expression in colon cancers was significantly associated to reduced patient survival (p=0.019) and disease-free interval (p=0.035), confirmed also in a multi-variate analysis.
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