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Hypertonic saline/dextran improves renal function after hemorrhage in conscious swine
J L Sondeen1, G A Gonzaludo, J A Loveday
1Division of Military Trauma Research, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129-6800.
Resuscitation
|December 1, 1990
Summary
Hypertonic saline/Dextran (HSD) effectively restored renal function and hemodynamics after severe hemorrhage in pigs. This resuscitation method offers sustained benefits compared to normal saline.
Area of Science:
- Physiology
- Resuscitation Medicine
- Nephrology
Background:
- Hemorrhage significantly impairs renal function, reducing blood flow and filtration.
- Restoring hemodynamics after hemorrhage is critical for organ function.
- The efficacy of hypertonic saline/Dextran (HSD) in preserving renal function post-hemorrhage requires further investigation.
Purpose of the Study:
- To evaluate the effectiveness of HSD resuscitation in restoring renal function following severe hemorrhage.
- To compare the effects of HSD with normal saline in a porcine hemorrhage model.
Main Methods:
- Conscious pigs with chronic instrumentation underwent hemorrhage (28 ml/kg).
- Resuscitation was performed with a single bolus of HSD (4 ml/kg).
- Hemodynamic parameters (MAP, CO, RBF, GFR, urine flow) and plasma osmolality/sodium were monitored.
Main Results:
- HSD significantly improved mean arterial pressure (MAP), cardiac output (CO), and renal blood flow (RBF) post-hemorrhage.
- Glomerular filtration rate (GFR) and urine flow (V) also showed significant recovery with HSD treatment.
- HSD effects were superior and more sustained than those of normal saline.
Conclusions:
- HSD resuscitation effectively restores hemodynamic stability and preserves renal function after hemorrhage.
- HSD offers a superior resuscitation strategy compared to normal saline for managing hemorrhagic shock.
- This study highlights HSD's potential in clinical settings for trauma and hemorrhage management.