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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Related Experiment Video

Updated: Jul 19, 2026

Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium
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Published on: May 18, 2021

Single-nucleotide polymorphisms in porcine mannan-binding lectin A.

Brandon N Lillie1, Natalie D Keirstead, E James Squires

  • 1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada.

Immunogenetics
|November 8, 2006
PubMed
Summary

Researchers identified genetic variations in pig mannan-binding lectin (MBL) genes. These defects in MBL-A and MBL-C may impact disease resistance in pigs, similar to human immune system variations.

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Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
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Last Updated: Jul 19, 2026

Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium
09:45

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Published on: May 18, 2021

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

Area of Science:

  • Immunogenetics
  • Comparative genomics
  • Innate immunity

Background:

  • Mannan-binding lectins (MBLs) are key innate immune proteins.
  • Human MBL2 gene polymorphisms affect immune function.
  • Porcine MBL1 and MBL2 genes encode MBL-A and MBL-C, respectively.

Purpose of the Study:

  • To investigate single-nucleotide polymorphisms (SNPs) in porcine MBL1 and MBL2 genes.
  • To assess the potential impact of these genetic variations on disease resistance in pigs.

Main Methods:

  • Single-strand conformational polymorphism (SSCP) analysis of MBL cDNAs from porcine liver.
  • Multiplex PCR to detect specific SNPs in MBL1.
  • Quantitative analysis of MBL gene expression in liver tissue.

Main Results:

  • Three SNPs were identified in the coding region of porcine MBL1, including a nonsynonymous SNP in the MBL-A collagen-like domain.
  • This MBL-A SNP was present in all European pig breeds studied, with varying allele frequencies.
  • No SNPs were found in the coding region of porcine MBL2, but MBL-C expression was highly variable.

Conclusions:

  • Some pigs possess a miscoding defect in MBL-A and a potential expression defect in MBL-C.
  • These defects are analogous to human MBL gene polymorphisms affecting immune responses.
  • Further research is needed to determine the precise impact on porcine disease resistance.